Highly enantioselective transfer hydrogenation of quinolines catalyzed by gold phosphates: achiral ligand tuning and chiral-anion control of stereoselectivity.
نویسندگان
چکیده
A little gold goes a long way: as little as 0.01 mol % of chiral gold phosphate is sufficient to afford the asymmetric transfer hydrogenation of quinolines with high stereoselectivity (up to 98 % ee). The achiral ligands on gold were found to have considerable effect on the catalytic efficiency.
منابع مشابه
Asymmetric hydrogenation of quinolines catalyzed by iridium complexes of BINOL-derived diphosphonites.
A chiral diphosphonite, derived from BINOL and with an achiral diphenyl ether backbone, is an excellent ligand for the Ir-catalyzed asymmetric hydrogenation of quinolines; achiral P-ligands serving as possible additives (ee = 73-96%).
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ورودعنوان ژورنال:
- Angewandte Chemie
دوره 51 45 شماره
صفحات -
تاریخ انتشار 2012